Single-Dose Psilocybin Treatment for Major Depressive Disorder

Depression
Written By Rob Mudge, M.A.
Psilocybin To Treat Major Depressive Disorder

Study

Psilocybin to treat Major Depressive Disorder. Randomized trial with 104 adults receiving either psilocybin or placebo combined with psychotherapy.

Results

Psilocybin recipients had significantly lower Montgomery-Asberg Depression Rating Scale scores compared to placebo group from baseline to day 8 and baseline to day 43.

Discussion

Psilocybin treatment paired with psychological support led to clinically significant sustained reduction in depressive symptoms, without serious adverse events.

Citation

Raison, C. L., Sanacora, G., Woolley, J., Heinzerling, K., Dunlop, B. W., Brown, R. T., Kakar, R., Hassman, M., Trivedi, R. P., Robison, R., Gukasyan, N., Nayak, S. M., Hu, X., O'Donnell, K. C., Kelmendi, B., Sloshower, J., Penn, A. D., Bradley, E., Kelly, D. F., Mletzko, T., … Griffiths, R. R. (2023). Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial. JAMA, 330(9), 843–853. doi:10.1001/jama.2023.14530

Link To Study

Rob Mudge, M.A.

Rob is a psychedelic therapist and integration coach who holds a Masters in Counseling Psychology from Boston College.

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Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
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Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomized clinical trial